Key result
Warfarin is linked to a ~2.4% higher incidence of clinically significant postextraction bleeding.
Why the study?
Does warfarin therapy increase the risk of clinically significant postextraction bleeding in patients undergoing simple dental extraction?
Cross-Sectional (n=2,817)
Yes
Does warfarin therapy increase the risk of clinically significant postextraction bleeding in patients undergoing simple dental extraction?
Effect estimate: Incidence difference 2.38% (95% CI 0.65% to 4.10%)
Absolute Event Rate: 2.77% vs 0.39%
Warfarin therapy with PT-INR < 3.0 is associated with a slight but significant increase in clinically significant postextraction bleeding compared to no anticoagulation.
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May warrant bleeding risk caution during extractions in warfarin users; leaves open need for randomized confirmation before practice change.
Hiroshi et al. (2014) conducted a cross-sectional in Dental extraction (n=2,817). Warfarin vs. No warfarin was evaluated on Clinically significant postextraction bleeding (Incidence difference 2.38%, 95% CI 0.65% to 4.10%). Warfarin therapy was associated with a higher incidence of clinically significant postextraction bleeding compared to no warfarin (2.77% vs 0.39%; incidence difference 2.38%, 95% CI 0.65-4.10%).
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