Temporal analysis of sickle cell disease mortality in adults (1999–2020): insights from the CDC WONDER database

This is the authors' abstract. We don't add key points for this paper.

Objectives: This study aimed to evaluate temporal trends in adult sickle cell disease (SCD) mortality in the United States from 1999 to 2020, stratified by age, sex, race, and geography, to identify disparities and guide targeted interventions. Methods: < 0.05. Conclusions: Adult SCD mortality in the United States has risen significantly from 1999 to 2020, with disproportionate increases among older adults, women, and individuals in the Southern region. The findings highlight urgent needs for targeted national interventions, development of age-specific care models, and implementation of equity-focused health policies to address persistent racial and regional disparities in SCD outcomes.