Key result
Angiotensin II AT2 receptor mediates growth inhibition and remodeling of the endothelial extracellular matrix by upregulating thrombospondin-1 expression in cultured endothelial cells.
Population
Microvascular endothelial cells derived from rat heart and macrovascular endothelial cells derived from…
Comparison
Angiotensin II (10 M), selective ANG II receptor… vs Control conditions
Design
Preclinical
Authors
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Extends AT2-thrombospondin-1 endothelial mechanisms in vitro; leaves open in vivo relevance and therapeutic translation in cardiovascular disease.
The AT2 receptor mediates growth inhibition and remodeling of the endothelial extracellular matrix by upregulating thrombospondin-1 expression in both macro- and micro-vascular endothelial cells.
Jens W. Fischer (2001) studied this question. Angiotensin II and receptor antagonists/agonists (Losartan, PD123177, CGP42112A) was evaluated on DNA-synthesis and expression of thrombospondin-1 (TSP-1) and fibronectin (FN). Angiotensin II AT2 receptor mediates growth inhibition and remodeling of the endothelial extracellular matrix by upregulating thrombospondin-1 expression in cultured endothelial cells.
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