Key result
The difference in early diastolic mitral annulus velocity between rest and exercise (∆E') was strongly correlated with anaerobic threshold (r = 0.744) and peak VO2 (r = 0.748).
Why the study?
Does the ability to increase left ventricular diastolic function during exercise correlate with exercise tolerance in men with sinus rhythm?
Observational (n=26)
No
Does the ability to increase left ventricular diastolic function during exercise correlate with exercise tolerance in men with sinus rhythm?
Effect estimate: r = 0.744
p-value: p=<0.0001
The ability to increase left ventricular diastolic function during exercise, as measured by the change in E' (DeltaE'), is strongly correlated with exercise tolerance.
∆E' may reflect exercise tolerance via diastolic reserve; leaves open validation for risk stratification or interventions in sinus rhythm.
Cardiac function during exercise is assumed to be important in determining exercise tolerance. The aims of this study were to evaluate changes in left ventricular diastolic function (LVDF) during exercise and its effect on exercise tolerance assessed by a noninvasive method, exercise-stress tissue Doppler echocardiography. Twenty-six men with sinus rhythm (controls, hypertension, and cardiomyopathy) underwent cardiopulmonary exercise testing. To assess LVDF during exercise, exercise-stress Doppler echocardiography was performed with a constant workload at rest, and at 50%, 100%, and 120% of anaerobic threshold (AT). Doppler variables related to LVDF increased significantly as the workload increased (P < 0.05). Resting E'correlated significantly with AT (r = 0.424, P = 0.0308) and peak VO(2) (r = 0.471, P = 0.0152). However, the difference in E'between rest and 120% AT (DeltaE') was closely correlated with AT (r = 0.744, P < 0.0001) and peak VO(2) (r = 0.748, P < 0.0001). Moreover, DeltaE'was correlated independently with AT (P = 0.0321) and peak VO(2) (P = 0.0192) by multiple regression analysis. These results suggest that the ability to increase LVDF during exercise is an important factor in determining exercise tolerance.
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Sekiguchi et al. (2009) conducted an observational in Preserved left ventricular systolic function (n=26). Exercise stress vs. Rest was evaluated on Correlation of the difference in early diastolic mitral annulus velocity (∆E') with anaerobic threshold (r = 0.744, p=<0.0001). The difference in early diastolic mitral annulus velocity between rest and exercise (∆E') was strongly correlated with anaerobic threshold (r = 0.744) and peak VO2 (r = 0.748).
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