Key result
Exercise E/E' correlates with invasive LVDP and identifies reduced exercise capacity with 90% specificity.
Why the study?
While resting E/E' approximates LVDP, validation of exercise E/E' with invasive hemodynamic measurement remains limited and its clinical implications are unclear.
Does the Doppler index of diastolic filling (E/E') during exercise correlate with invasively measured LVDP and predict reduced exercise capacity?
Population
37 patients undergoing left heart catheterization and 166 patients undergoing treadmill exercise
Comparison
Exercise E/E' vs invasive LVDP and exercise capacity
Design
Validation and cross-sectional study
Authors
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May aid noninvasive diagnosis of exertional diastolic dysfunction; leaves open need for prospective validation.
Observational (n=203)
Does the Doppler index of diastolic filling (E/E') during exercise correlate with invasively measured LVDP and predict reduced exercise capacity?
Effect estimate: r = 0.59
Exercise E/E' correlates with invasively measured LVDP and a cutoff >13 reliably identifies patients with elevated LVDP and reduced exercise capacity.
James E. Sharman (2006) conducted an observational in Elevated left ventricular diastolic pressure and reduced exercise capacity (n=203). Exercise E/E' ratio (early diastolic transmitral velocity to early diastolic tissue velocity) vs. Invasive left ventricular diastolic pressure (LVDP) was evaluated on Correlation between E/E' and LVDP during exercise (r = 0.59). The exercise E/E' ratio correlated with invasively measured LVDP during exercise (r = 0.59), and a post-exercise E/E' >13 was 90% specific for reduced exercise capacity (<8 METs).
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