Key result
LAVI/A' ratio ≥3.0 predicts HF hospitalization and mortality in patients with ACS.
Why the study?
Does the echocardiographic LAVI/A' ratio predict heart failure hospitalization and mortality in patients with acute coronary syndrome?
Observational (n=212)
Does the echocardiographic LAVI/A' ratio predict heart failure hospitalization and mortality in patients with acute coronary syndrome?
p-value: p=0.0021
The echocardiographic LAVI/A' ratio is a useful prognostic marker for predicting heart failure events in patients with acute coronary syndrome, particularly NSTE-ACS.
Supports LAVI/A' ratio for HF risk stratification in ACS; leaves open prospective validation before practice change.
PURPOSE: The ratio of the left atrial volume index (LAVI) and late diastolic mitral annular velocity (A') is a useful echocardiographic index for identifying advanced left ventricular (LV) diastolic dysfunction in patients with dyspnoea. We investigated the clinical implications and prognostic value of the aforementioned ratio (LAVI/A') in patients with ST elevation (STE) or non-STE (NSTE) acute coronary syndrome (ACS). METHODS: We studied 212 patients with ACS. All patients underwent electrocardiography, echocardiography and measurement of plasma B-type natriuretic peptide (BNP) level on admission. The study endpoints were hospitalisation and mortality because of heart failure (HF). RESULTS: There was a significant, moderate positive correlation between LAVI/A' and natural logarithm (Ln) BNP level among the participants (r=0.48, p<0.0001). During a mean follow-up of 17 months, eight patients died and nine patients were hospitalised because of HF. The receiver operating characteristics curve indicated that LAVI/A'≥3.0 predicted these events (log-rank, p=0.0021). A significant and moderate positive correlation existed between LAVI/A' and Ln BNP level in the NSTE-ACS group (n=128; r=0.58, p<0.0001). However, the correlation between LAVI/A' and Ln BNP level was weaker in the STE-ACS group (n=84; r=0.33, p=0.0017). CONCLUSION: LAVI/A' was related to plasma BNP levels in patients with ACS, particularly in those with NSTE-ACS. This index was useful for predicting cardiac events in patients with ACS.
No takes yet. Share an insight, caveat, or question.
Matsuura et al. (2018) conducted an observational in Acute coronary syndrome (n=212). LAVI/A' ratio was evaluated on Hospitalisation and mortality because of heart failure (p=0.0021). A LAVI/A' ratio ≥3.0 significantly predicted hospitalization and mortality due to heart failure in patients with acute coronary syndrome over a mean follow-up of 17 months (log-rank p=0.0021).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: