Key result
Females exhibit higher coronary tortuosity than males, correlating with diastolic dysfunction and higher NYHA class.
Why the study?
Gender differences in cardiovascular disease pose challenges, and coronary vessel tortuosity is common with a significant prevalence in women and known hemodynamic effects.
Does coronary tortuosity correlate with diastolic dysfunction and heart failure symptoms in patients with low to intermediate cardiovascular risk?
Observational (n=149)
No
Does coronary tortuosity correlate with diastolic dysfunction and heart failure symptoms in patients with low to intermediate cardiovascular risk?
Absolute Event Rate: 1.99% vs 0.91%
p-value: p=<0.001
Coronary tortuosity is significantly more prevalent in women and correlates with diastolic dysfunction and worse NYHA class, suggesting it may be an anatomical risk factor contributing to HFpEF.
Coronary tortuosity may mark diastolic dysfunction risk in women; leaves open causal role in HFpEF and requires prospective validation.
Gender differences in cardiovascular disease represent a great challenge for cardiology. Coronary vessel tortuosity is common anatomical feature that shows significant prevalence in women.Tortuosity modifies vessels hemodinamyc; coronary tortuosity is related to helical flow which results in a reduction of myocardial perfusion pressure and in increase of shear stress and microcirculatory resistance. 149 patients (78 males;71 females), with low to intermediate cardiovascular risk and no previous history of CAD, who underwent coronary CT scan were included in this retrospective study. All patients who underwent CCT were admitted to our institution with no cardiac symptoms and low or intermediate cardiovascular risk, according to ESC guidelines. It can be observed that there is a positive, strong and statistically significant relationship between NYHA and all the other variable. In our study we demostrate correlation between coronary tortuosity, diastolic disfunction and symptoms.
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Donna et al. (2023) conducted an observational in Low to intermediate cardiovascular risk without previous history of CAD (n=149). Female gender vs. Male gender was evaluated on Coronary tortuosity score of IVA (LADA) (p=<0.001). Female patients exhibited significantly higher coronary tortuosity scores compared to males, which strongly correlated with diastolic dysfunction and higher NYHA functional class.
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