Key result
Acute left ventricular pressure overload via aortic constriction increased intrapericardial pressure by an average of 3.4 mm Hg at any given fluid volume during cardiac tamponade (p<0.001).
Why the study?
Does acute left ventricular pressure overload alter the relationship between intrapericardial pressure and fluid volume during cardiac tamponade in dogs?
Population
5 spontaneously breathing dogs
Comparison
Acute left ventricular pressure overload induced… vs Cardiac tamponade without aortic constriction
Design
Preclinical
Authors
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May hasten tamponade physiology in LV overload; leaves open human translation.
Does acute left ventricular pressure overload alter the relationship between intrapericardial pressure and fluid volume during cardiac tamponade in dogs?
Effect estimate: 3.4 mm Hg higher IPP
p-value: p=<0.001
Acute left ventricular pressure overload increases intrapericardial pressure for a given effusion volume, precipitating earlier right ventricular diastolic collapse during cardiac tamponade.
Cogswell et al. (1986) studied Cardiac tamponade (n=5). Aortic constriction vs. Absence of aortic constriction was evaluated on Intrapericardial pressure at any given intrapericardial fluid volume and at the onset of right ventricular diastolic collapse (3.4 mm Hg higher IPP, p=<0.001). Acute left ventricular pressure overload via aortic constriction increased intrapericardial pressure by an average of 3.4 mm Hg at any given fluid volume during cardiac tamponade (p<0.001).
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