Key result
Increasing pericardial pressure decreased left ventricular diameters, and the decline in end-systolic diameter during tamponade was significantly reduced by propranolol.
Why the study?
Does increasing pericardial pressure alter left ventricular internal diameter, and how does beta-adrenergic blockade affect this response in anesthetized dogs?
Population
Closed chest, anaesthetized dogs
Comparison
Increasing intrapericardial pressure via… vs Baseline state and pre-propranolol state
Design
Preclinical
Authors
Loading...
Beta-adrenergic blockade may blunt LV adaptation in tamponade; leaves open translation to clinical pericardial disease.
Does increasing pericardial pressure alter left ventricular internal diameter, and how does beta-adrenergic blockade affect this response in anesthetized dogs?
The study demonstrates that beta-adrenergic receptors are crucial for the systolic reserve adaptation of the left ventricle during pericardial tamponade.
Pegram et al. (1975) studied Pericardial tamponade. Increasing pericardial pressure and propranolol was evaluated on Left ventricular internal diameter. Increasing pericardial pressure decreased left ventricular diameters, and the decline in end-systolic diameter during tamponade was significantly reduced by propranolol.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: