Key result
Heart failure is a complex condition driven by an imbalance between vasodilator and vasoconstrictor mechanisms, where neurohormonal activation precipitates structural changes and disease progression.
Heart failure pathophysiology is driven by a deleterious imbalance in neurohormonal systems, leading to disease progression.
Reinforces neurohormonal blockade as HF therapy cornerstone; leaves open precise pathway targeting for future trials.
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Komajda et al. (1998) conducted a review in Congestive heart failure. Heart failure is a complex condition driven by an imbalance between vasodilator and vasoconstrictor mechanisms, where neurohormonal activation precipitates structural changes and disease progression.
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