Key result
Neuroendocrine changes directly worsen heart failure and prognosis, while interventions that antagonize these changes, such as ACE inhibitors, reduce mortality.
Population
Patients with heart failure
Design
Review
Authors
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Supports ACEI use via neuroendocrine blockade in HF; leaves open optimal sequencing with contemporary GDMT.
This review highlights the central role of neuroendocrine activation in the pathophysiology and progression of heart failure, providing a mechanistic rationale for the mortality benefits of ACE inhibitors and the harm of positive inotropes.
William W. Parmley (1995) conducted a review in Heart failure. Neuroendocrine changes was evaluated. Neuroendocrine changes directly worsen heart failure and prognosis, while interventions that antagonize these changes, such as ACE inhibitors, reduce mortality.
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