Key result
Neurohumoral activation plays a key role in heart failure progression, and therapies targeting these pathways, including the newer ARNI sacubitril/valsartan, are reviewed.
Design
Review
Authors
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Should not yet change HF management; leaves open incremental roles for AVP antagonism beyond volume control.
This review summarizes the role of neurohumoral activation in heart failure progression and the mechanisms of therapies targeting these pathways.
Antonis S. Manolis (2023) conducted a review in Heart failure. Neurohumoral antagonists was evaluated. Neurohumoral activation plays a key role in heart failure progression, and therapies targeting these pathways, including the newer ARNI sacubitril/valsartan, are reviewed.
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