Key result
Therapeutic modulation of neurohumoral activation is key to successful heart failure treatment, as compensatory activation contributes to disease progression and poor prognosis.
This review highlights that compensatory neurohumoral activation contributes to the development and poor prognosis of heart failure, making it a key therapeutic target.
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Affirms neurohumoral modulation as HF cornerstone; leaves open optimization across phenotypes.
Middlekauff et al. (1998) conducted a review in Heart failure. Therapeutic modulation of neurohumoral activation was evaluated. Therapeutic modulation of neurohumoral activation is key to successful heart failure treatment, as compensatory activation contributes to disease progression and poor prognosis.
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