Key result
Intramural electrical mapping and modeling revealed left ventricular myocardium has unique bulk conductivities in the myofiber direction, parallel, and normal to myolaminae in a 4:2:1 ratio.
Population
Left ventricular myocardium (experimental and computer models)
Design
Preclinical
Authors
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Supports orthotropic conductivity models in simulations; leaves open validation and translation to human hearts.
Cardiac tissue acts as an electrically orthotropic substrate with distinct conductivities along three microstructural axes, challenging the traditional view of transverse isotropy.
Hooks et al. (2007) studied Cardiac electrical anisotropy. Intramural electrical mapping and computer modeling was evaluated on Bulk conductivities associated with three microstructurally-defined axes. Intramural electrical mapping and modeling revealed left ventricular myocardium has unique bulk conductivities in the myofiber direction, parallel, and normal to myolaminae in a 4:2:1 ratio.
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