Key result
High-density intramural electric mapping in 5 pig hearts showed electrically orthotropic ventricular tissue with conduction velocities of 0.67, 0.30, and 0.17 ms(-1) along 3 microstructural axes.
Population
Pig left ventricular tissue (n=5 hearts)
Design
Preclinical
Authors
Loading...
Challenges isotropic assumptions in ventricular models; leaves open integration into human arrhythmia simulations.
Ventricular tissue is electrically orthotropic with three distinct propagation directions, challenging the assumption of uniform side-to-side electrical coupling and highlighting the need to include laminar myocardial architecture in arrhythmia models.
Caldwell et al. (2009) studied Ventricular myocardium electrical propagation (n=5). High-density intramural electric mapping was evaluated on Conduction velocity in distinct propagation directions. High-density intramural electric mapping in 5 pig hearts showed electrically orthotropic ventricular tissue with conduction velocities of 0.67, 0.30, and 0.17 ms(-1) along 3 microstructural axes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: