Key result
Activation across myocardial fibers, rather than parallel to them, significantly enhanced high frequency notching of QRS complexes in an in vivo cardiac model (P<0.001).
Why the study?
Does activation across myocardial fibers produce high frequency notching of QRS complexes in an in vivo cardiac model?
Does activation across myocardial fibers produce high frequency notching of QRS complexes in an in vivo cardiac model?
p-value: p=<0.001
This preclinical study demonstrates that cross-fiber activation is a mechanism for high frequency notching of QRS complexes.
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Provides mechanistic insight into QRS notching; leaves open translation to human ECG interpretation or outcomes.
Vanderark et al. (1975) studied High frequency notching of QRS complexes. Epicardial stimulation across myocardial fibers vs. Stimulation parallel to myocardial fibers was evaluated on Notched QRS complexes based on propagation direction (p=<0.001). Activation across myocardial fibers, rather than parallel to them, significantly enhanced high frequency notching of QRS complexes in an in vivo cardiac model (P<0.001).
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