Key result
Patients with hypertrophic cardiomyopathy had significantly higher insulin resistance (HOMA-IR 2.90±1.22) compared to those with essential hypertension (1.69±0.77) and normotensive controls (0.91±0.24).
Why the study?
Is insulin resistance increased in patients with hypertrophic cardiomyopathy compared to hypertensive and normotensive controls, and is it related to clinical manifestations?
Observational (n=105)
Is insulin resistance increased in patients with hypertrophic cardiomyopathy compared to hypertensive and normotensive controls, and is it related to clinical manifestations?
Patients with hypertrophic cardiomyopathy exhibit significantly higher insulin resistance compared to hypertensive and normotensive controls, which is independently associated with left ventricular pressure gradient, septal thickness, and BMI, and may be linked to sudden death.
Answers are grounded in this paper and cite their sources.
Insulin resistance was associated with hypertrophic cardiomyopathy severity; this leaves open its causal role and need for prospective studies.
BACKGROUND: The aim of the present study was to investigate whether or not insulin resistance is present in hypertrophic cardiomyopathy (HCM), and also whether it is related to the clinical manifestations of HCM. METHODS AND RESULTS: The study group comprised 55 patients with HCM, 35 with essential hypertension (EHT) and 15 normotensive control subjects (NC). An insulin resistance index was estimated using the homeostasis model assessment (HOMA-IR) of fasting insulin - glucose interactions. In patients with HCM, prognosis and cardiovascular events were also checked. The HOMA-IR values in the HCM group (2.90+/-1.22) were significantly higher than those in the EHT (1.69+/-0.77) and NC groups (0.91+/-0.24). The HOMA-IR values in the EHT group were significantly higher than those in the NC group. Multiple regression analyses determined that left ventricular pressure gradient without provocation (p<0.0001), interventricular septal thickness (p=0.0143) and body mass index (p=0.0412) were independent determinants of insulin resistance in patients with HCM. During a mean follow-up of 105+/-50 months, 4 patients with HCM died suddenly and all of them had high HOMA-IR values. CONCLUSIONS: The results suggest that patients with HCM without apparent diabetes mellitus or hypertension have insulin resistance and that insulin resistance may be related to the manifestations of HCM.
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Murakami et al. (2004) conducted an observational in Hypertrophic cardiomyopathy (n=105). Hypertrophic cardiomyopathy vs. Essential hypertension and normotensive controls was evaluated on Insulin resistance index (HOMA-IR). Patients with hypertrophic cardiomyopathy had significantly higher insulin resistance (HOMA-IR 2.90±1.22) compared to those with essential hypertension (1.69±0.77) and normotensive controls (0.91±0.24).
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