Key result
Among 288 participants, N/L ratio and C-IMT values were significantly higher in patients with cardiac syndrome X and coronary artery disease compared to normal controls.
Why the study?
Are Neutrophils/Lymphocytes ratio and carotid intima-media thickness increased in patients with cardiac syndrome X compared to normal participants and those with coronary artery disease?
Observational (n=288)
Are Neutrophils/Lymphocytes ratio and carotid intima-media thickness increased in patients with cardiac syndrome X compared to normal participants and those with coronary artery disease?
Patients with cardiac syndrome X have elevated N/L ratio and C-IMT comparable to CAD patients, suggesting a role for endothelial dysfunction and inflammation in its pathogenesis.
Supports inflammation in CSX pathogenesis; hypothesis-generating and requires prospective validation before clinical adoption.
Neutrophils and lymphocytes (N/L) ratio and carotid intima-media thickness (C-IMT) value have been studied as new predictors of cardiovascular risk. We aimed to investigate N/L ratio and C-IMT value in patients with cardiac syndrome X (CSX) and compare patients with coronary artery disease (CAD) and normal participants. A total of 288 participants were enrolled in the study. The N/L ratio and C-IMT value were compared among the 3 groups. There were no statistically significant differences in N/L levels between CSX and CAD groups. The N/L ratio was found significantly increased in patients with CSX and CAD, compared to the control group. Patients with CAD and CSX had significantly higher C-IMT value compared to control participants. Significant positive correlation was found between C-IMT value and plasma level of N/L ratio. The relationship among CSX and higher N/L ratio level and C-IMT suggests that endothelial dysfunction may contribute to the etiopathogenesis of the CSX.
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Demırkol et al. (2012) conducted an observational in Cardiac syndrome X (n=288). Neutrophils/Lymphocytes ratio and Carotid Intima-Media Thickness vs. Normal participants was evaluated on N/L ratio and C-IMT value. Among 288 participants, N/L ratio and C-IMT values were significantly higher in patients with cardiac syndrome X and coronary artery disease compared to normal controls.
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