Key result
Elevated monocyte-to-HDL cholesterol ratio was significantly higher in patients with cardiac syndrome X compared to controls (0.011 vs 0.010; P<0.001) and independently associated with the condition.
Why the study?
Is elevated monocyte-to-HDL cholesterol ratio associated with cardiac syndrome X?
Case-Control (n=230)
Is elevated monocyte-to-HDL cholesterol ratio associated with cardiac syndrome X?
Absolute Event Rate: 0.011% vs 0.01%
p-value: p=<0.001
Elevated monocyte-to-HDL cholesterol ratio is independently associated with cardiac syndrome X and may serve as an additive predictive marker.
OBJECTIVE: Cardiac syndrome X (CSX) is typically identified with ischaemia in treadmill exercise test or stress myocardial perfusion scintigraphy as well as angina-like chest pain without stenosis in coronary angiography. The purpose of the present study is to investigate the association between cardiac syndrome X and monocyte-to-HDL cholesterol ratio (MHR) which is a new marker associated with inflammation. PATIENTS AND METHODS: A total of 230 patients (105 patients with cardiac syndrome X and 125 normal controls) were included in the study. Peripheral venous blood samples were drawn from all study population before coronary angiography for measuring MHR and other haematological parameters. RESULTS: The patients with cardiac syndrome X were more likely to have higher platelet counts, plateletcrit (PCT), monocyte count and MHR values. Monocyte count and MHR of the CSX group were significantly higher than the control group [0.53 (0.35-1) vs. 0.49 (0.23-0.96); p = .002, .011 (0.006-0.038) vs. 0.010 (0.004-0.034); p < .001, respectively]. HDL-cholesterol levels of the CSX group were significantly lower than the control groups (46.3 ± 10.1 vs. 49.6 ± 11.6; p = .021). Higher MHR and PCT values were found to be associated with the presence of CSX by multivariate logistic regression analysis. CONCLUSIONS: Elevated MHR level independently was found in association with the presence of CSX. The value of MHR appears additive to conventional expensive methods commonly used in CSX prediction.
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Doğan et al. (2017) conducted a case-control in Cardiac syndrome X (n=230). Monocyte-to-HDL cholesterol ratio (MHR) vs. Normal controls was evaluated on Monocyte-to-HDL cholesterol ratio (p=<0.001). Elevated monocyte-to-HDL cholesterol ratio was significantly higher in patients with cardiac syndrome X compared to controls (0.011 vs 0.010; P<0.001) and independently associated with the condition.
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