October 20, 2010Journal of Cardiovascular Medicine
Relation between cardiovascular risk factors and coronary microvascular dysfunction in cardiac syndrome X
Why the study?
Do cardiovascular risk factors and CRP levels predict coronary microvascular dysfunction in patients with cardiac syndrome X?
Population
71 patients with cardiac syndrome X and 20 healthy volunteers
Comparison
Assessment of cardiovascular risk factors and… vs Healthy volunteers
Design
Case-control
Authors
Discussion
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Implication
CVRFs including CRP do not predict microvascular dysfunction in CSX; leaves open nontraditional mechanisms for prospective study.
Structured PICO
Do cardiovascular risk factors and CRP levels predict coronary microvascular dysfunction in patients with cardiac syndrome X?
P
Population
71 patients with cardiac syndrome X (CSX) (mean age 56 ± 9 years, 23 men) and 20 healthy volunteers (mean age 52 ± 7 years, 9 men)
I
Intervention
Assessment of cardiovascular risk factors (CVRFs) and C-reactive protein (CRP) levels
C
Comparator
Healthy volunteers
O
Outcome
Coronary microvascular vasodilator function assessed by transthoracic Doppler echocardiography (ratio of diastolic coronary blood flow velocity at peak intravenous adenosine and during cold pressor test to basal values)surrogate
Common cardiovascular risk factors and CRP levels do not reliably predict endothelium-dependent or endothelium-independent coronary microvascular dysfunction in patients with cardiac syndrome X.
Cite This Study
Sestito et al. (2010) studied this question.