Key result
Cardiac syndrome X was associated with worse endothelial function than healthy controls, but better endothelial function than coronary artery disease.
Why the study?
Does endothelial function differ between patients with cardiac syndrome X, coronary artery disease, and healthy controls?
Observational
Does endothelial function differ between patients with cardiac syndrome X, coronary artery disease, and healthy controls?
Patients with cardiac syndrome X exhibit impaired endothelial function compared to healthy controls, though the impairment is less severe than in patients with obstructive coronary artery disease.
Supports endothelial assessment in cardiac syndrome X research; should not yet alter clinical practice or guidelines.
Cardiac syndrome X (CSX) differs from coronary artery disease (CAD) and is characterized by angina, positive stress test, and patent coronary arteries. The probable mechanism is a microvascular disorder associated with endothelial dysfunction. In this study, brachial artery flow-mediated vasodilation was used as well as the endothelin-1 assay to assess endothelial function in patients with cardiac syndrome X (CSX), coronary artery disease (CAD), and healthy controls. All subjects underwent a 2-step brachial artery flow-related vasodilatation test. Serum endothelin-1, one of the most potent constricting factors, was measured for all participants. Patients with CSX had a lower brachial artery dilation ratio than controls but higher than that of CAD patients. Control subjects and CSX patients had higher endothelin-1 levels than CAD patients. CSX patients were found to have worse endothelial function than healthy volunteers, but patients with CAD had even worse endothelium function than CSX patients.
No takes yet. Share an insight, caveat, or question.
Li et al. (2008) conducted an observational in Cardiac syndrome X. Cardiac syndrome X vs. Coronary artery disease and healthy controls was evaluated on Brachial artery flow-mediated vasodilation and serum endothelin-1 levels. Cardiac syndrome X was associated with worse endothelial function than healthy controls, but better endothelial function than coronary artery disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: