Key result
Hospitalization region in Japan shows no association with post-discharge cardiac outcomes in HFrEF patients.
Why the study?
Regional variations in clinical practice and prognosis among patients hospitalized with HFrEF in Japan remained to be clarified.
Observational (n=4,329)
Yes
This nationwide registry study demonstrates that despite some regional age differences, post-discharge prognosis for HFrEF patients is consistent across Japan.
Answers are grounded in this paper and cite their sources.
Supports uniform HFrEF outcomes across Japan; leaves open generalizability to other healthcare systems.
BACKGROUND: The present study aimed to clarify the regional variations in clinical practice and the prognosis of patients with heart failure with reduced ejection fraction (HFrEF) in Japan using the Japanese Registry of Acute Decompensated Heart Failure (JROADHF). METHODS AND RESULTS: We recruited data of hospitalized patients with HFrEF (n=4,329) from the JROADHF. The patients were divided into 6 groups based on the region of Japan where they were hospitalized: Hokkaido-Tohoku (n=504), Kanto (n=958), Chubu (n=779), Kinki (n=902), Chugoku-Shikoku (n=446), and Kyushu (n=740). We compared the patients' characteristics, including etiology of HF and prognosis after discharge. The age of the patients was lowest in the Kanto and Kinki regions. In contrast, there were no differences in the prevalence of comorbidities, levels of B-type natriuretic peptide, or left ventricular EF among the 6 groups. Post-discharge cardiospecific prognosis, specifically, the composite of cardiac death or HF hospitalization, cardiac death, and HF hospitalization, was comparable among the 6 regions. CONCLUSIONS: There were no differences in cardiospecific prognosis in patients with HFrEF among the 6 regions in Japan.
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Sato et al. (2023) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) (n=4,329). Region of hospitalization vs. Comparison among 6 geographic regions was evaluated on Post-discharge cardiospecific prognosis (composite of cardiac death or HF hospitalization, cardiac death, and HF hospitalization). Among 4,329 hospitalized patients with HFrEF, the region of hospitalization in Japan showed no differences in post-discharge cardiospecific prognosis.
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