Why the study?
Increasing diuretic resistance in acutely decompensated heart failure requires attention, particularly after trials combining diuretic categories failed to yield expected results.
Answers are grounded in this paper and cite their sources.
This comprehensive review summarizes the pathophysiology of congestion in heart failure and highlights ultrafiltration as a potential alternative or adjunctive therapy for patients with diuretic resistance.
This review paper presents a review of the evolution of this disease throughout the centuries, describes and summarizes the pathophysiologic mechanisms, briefly discusses the mechanism of action of diuretics, presents their role in decongesting heart failure in patients, and reveals the data behind ultrafiltration in the management of acutely or chronically decompensated heart failure (ADHF), focusing on all the available data and advancements in this field. Acutely decompensated heart failure (ADHF) presents a critical clinical condition characterized by worsening symptoms and signs of heart failure, necessitating prompt intervention to alleviate congestion and improve cardiac function. Diuretics have traditionally been the mainstay for managing fluid overload in ADHF. Mounting evidence suggests that due to numerous causes, such as coexisting renal failure or chronic use of loop diuretics, an increasing rate of diuretic resistance is noticed and needs to be addressed. There has been a series of trials that combined diuretics of different categories without the expected results. Emerging evidence suggests that ultrafiltration may offer an alternative or adjunctive approach.
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Alevroudis et al. (2023) conducted a review in Acutely or chronically decompensated heart failure (ADHF). Ultrafiltration and diuretics was evaluated.
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