Key result
Higher claims-based frailty index linked to ~73% greater 1-year mortality in aortic valve disease.
Why the study?
In aortic valve disease, the relationship between claims-based frailty indices and validated measures constructed from in-person assessments is unclear.
Does a higher claims-based frailty index predict increased mortality and adverse events in older adults with aortic valve disease?
Population
2357 adults aged ≥65 years in the US CoreValve Studies linked to Medicare inpatient claims
Comparison
Higher vs lower Johns Hopkins claims-based frailty index tertiles
Design
Retrospective cohort linkage substudy (EXTEND-FRAILTY)
Follow-up
1 year
Authors
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May inform prognosis via claims data when in-person frailty assessment is unavailable; leaves open prospective validation for risk stratification.
Observational (n=2,357)
Yes
Does a higher claims-based frailty index predict increased mortality and adverse events in older adults with aortic valve disease?
Effect estimate: HR 1.73 (95% CI 1.41-2.12)
Absolute Event Rate: 31.3% vs 19.3%
p-value: p=<0.001
A claims-based frailty index can validly identify frailty status and predict mortality and adverse events in older adults with aortic valve disease when in-person assessments are unavailable.
Strom et al. (2021) conducted an observational in Aortic valve disease (n=2,357). Claims-based frailty index (CFI) tertile 3 vs. CFI tertile 1 was evaluated on All-cause mortality at 1 year (HR 1.73, 95% CI 1.41-2.12, p=<0.001). A higher claims-based frailty index (tertile 3 vs 1) was associated with an increased risk of 1-year all-cause mortality (31.3% vs 19.3%; HR 1.73; 95% CI 1.41-2.12; P<0.001) in aortic valve disease.
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