Key result
Postoperative dexmedetomidine infusion targeting 600 pg/mL overshot target plasma concentrations (median percent error 21%) and decreased norepinephrine from 2.1 to 0.7 nmol/L.
Why the study?
Does dexmedetomidine infused by computer-controlled infusion protocol achieve target plasma concentrations and attenuate sympathetic activity in postoperative women?
Population
8 women in the immediate postoperative period
Design
Cohort
Follow-up
3 hours after the end of infusion
Authors
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Overshooting targets with published PK models cautions dosing accuracy postoperatively; leaves open whether computer-controlled dexmedetomidine reliably attenuates sympathetic activity.
Does dexmedetomidine infused by computer-controlled infusion protocol achieve target plasma concentrations and attenuate sympathetic activity in postoperative women?
Dexmedetomidine infusion by computer-controlled infusion protocol using published pharmacokinetic parameters overshoots target concentrations but effectively attenuates sympathetic activity in the early postoperative period.
Talke et al. (1997) studied Surgical patients in the immediate postoperative period (n=8). Dexmedetomidine was evaluated on Pharmacokinetics of dexmedetomidine, precision of CCIP, and sympatholytic effects. Postoperative dexmedetomidine infusion targeting 600 pg/mL overshot target plasma concentrations (median percent error 21%) and decreased norepinephrine from 2.1 to 0.7 nmol/L.
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