Key result
Dexmedetomidine blunts MAP and HR spikes during intubation and extubation vs propofol but increases bradycardia.
Why the study?
Thoracotomy is associated with hemodynamic consequences, and the study aimed to evaluate the effect of dexmedetomidine infusion on hemodynamics during thoracic surgery.
Does dexmedetomidine improve hemodynamic stability during thoracic surgery compared to propofol?
RCT (n=78)
Single-blind
Computer-generated random number table
No
Does dexmedetomidine improve hemodynamic stability during thoracic surgery compared to propofol?
p-value: p=<0.05
Dexmedetomidine effectively blunts the hemodynamic stress response during intubation and extubation in thoracic surgery compared to propofol, though it increases the risk of bradycardia and hypotension.
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Dexmedetomidine may aid hemodynamic stability in thoracic surgery; leaves open confirmation in randomized trials.
Agarwal et al. (2021) conducted an RCT in Thoracic surgery (n=78). Dexmedetomidine vs. Propofol (200 μg/kg/min infusion) was evaluated on Mean arterial pressure (MAP) and heart rate at intubation, intraoperatively, and at extubation (p=<0.05). Dexmedetomidine infusion significantly reduced the rise in mean arterial pressure and heart rate during intubation and extubation compared to propofol (p<0.05), but increased the need for treatment of bradycardia and hypotension.