Key result
Dexmedetomidine significantly attenuated the percentage increase in heart rate after intubation compared to placebo (7.04% vs 15.08%) in patients undergoing CABG surgery.
Why the study?
CABG surgery involves noxious stimuli that cause stress responses, increasing the risk of perioperative myocardial ischemia, and the effect of dexmedetomidine on attenuating these hemodynamic responses was evaluated.
Does dexmedetomidine attenuate the hemodynamic response to intubation, skin incision, and sternotomy in patients undergoing CABG surgery?
RCT (n=60)
Double-blind
Computer-generated random number table
Does dexmedetomidine attenuate the hemodynamic response to intubation, skin incision, and sternotomy in patients undergoing CABG surgery?
Absolute Event Rate: 7.04% vs 15.08%
p-value: p=<0.01
Dexmedetomidine significantly attenuates the hemodynamic stress response during CABG surgery and reduces the required induction dose of thiopentone.
Authors
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Supports dexmedetomidine to blunt hemodynamic responses in CABG; extends RCT evidence for perioperative use.
Singariya et al. (2020) conducted an RCT in Coronary artery bypass graft (CABG) surgery (n=60). Dexmedetomidine vs. Placebo (normal saline) was evaluated on Percentage increase in heart rate after intubation (p=<0.01). Dexmedetomidine significantly attenuated the percentage increase in heart rate after intubation compared to placebo (7.04% vs 15.08%) in patients undergoing CABG surgery.
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