Key result
Intravenous dexmedetomidine infusion in healthy males produced a transient increase in mean arterial blood pressure followed by a dose-dependent decrease of up to 27% at 60 minutes (P<0.05).
Why the study?
Does intravenous dexmedetomidine alter hemodynamic parameters in healthy male volunteers?
RCT (n=37)
double-blind
randomized
Does intravenous dexmedetomidine alter hemodynamic parameters in healthy male volunteers?
p-value: p=<.05
A 2-minute intravenous infusion of dexmedetomidine in healthy males produces a transient initial increase followed by a longer-lasting decrease in blood pressure and catecholamines, and is well tolerated.
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Clinicians should anticipate and monitor for biphasic MAP changes with dexmedetomidine; confirms hemodynamic effects in this RCT of healthy males.
Bloor et al. (1992) conducted an RCT in Healthy volunteers (n=37). Dexmedetomidine (DMED) vs. Placebo was evaluated on Hemodynamic effects including mean arterial blood pressure (MABP), heart rate, and cardiac output (p=<.05). Intravenous dexmedetomidine infusion in healthy males produced a transient increase in mean arterial blood pressure followed by a dose-dependent decrease of up to 27% at 60 minutes (P<0.05).
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