Key result
In autonomically denervated dogs, dexmedetomidine increased mean arterial pressure by 98% and systemic vascular resistance index by 376%, while decreasing cardiac index by 59%.
Why the study?
Does dexmedetomidine affect hemodynamic parameters in anesthetized, autonomically denervated dogs?
Does dexmedetomidine affect hemodynamic parameters in anesthetized, autonomically denervated dogs?
Dexmedetomidine causes potent arteriolar and venous constriction in autonomically denervated dogs, leading to decreased cardiac index and increased filling pressures that are reversible by atipamezole.
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May elevate afterload and filling pressures in denervated states; leaves open direct vascular effects in humans.
Flacke et al. (1990) studied Autonomically denervated dogs (n=8). Dexmedetomidine was evaluated on Hemodynamic effects (MAP, CI, SVRI, LVEDP). In autonomically denervated dogs, dexmedetomidine increased mean arterial pressure by 98% and systemic vascular resistance index by 376%, while decreasing cardiac index by 59%.
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