Key result
A pre-induction bolus of dexmedetomidine 0.6 µg/kg significantly attenuated postintubation heart rate increases compared to fentanyl (18 vs 26 beats/min; P<0.05) during abdominal hysterectomy.
Why the study?
Does intravenously administered dexmedetomidine improve perioperative hemodynamics and reduce isoflurane requirements in women undergoing abdominal hysterectomy?
Population
96 women undergoing abdominal hysterectomy
Comparison
Dexmedetomidine as a single intravenous bolus… vs Fentanyl 2.0 micrograms.kg-1 or saline as a…
Design
RCT, randomized, double-blind
Follow-up
perioperative
Authors
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Supports dexmedetomidine pre-induction to blunt intubation tachycardia versus fentanyl; extends RCT evidence for hemodynamic stability in gynecologic surgery.
RCT (n=96)
Double-blind
randomized
Does intravenously administered dexmedetomidine improve perioperative hemodynamics and reduce isoflurane requirements in women undergoing abdominal hysterectomy?
Absolute Event Rate: 18% vs 26%
p-value: p=<0.05
A 0.6 mcg/kg dose of dexmedetomidine administered before anesthesia induction significantly blunts hemodynamic responses to intubation compared to saline or fentanyl in women undergoing abdominal hysterectomy.
Aho et al. (1991) conducted an RCT in Abdominal hysterectomy (n=96). Dexmedetomidine vs. Fentanyl 2.0 micrograms.kg-1 or saline was evaluated on Postintubation increase in heart rate (beats per min) (p=<0.05). A pre-induction bolus of dexmedetomidine 0.6 µg/kg significantly attenuated postintubation heart rate increases compared to fentanyl (18 vs 26 beats/min; P<0.05) during abdominal hysterectomy.
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