Key result
Adjuvant use of multiple drug agents may present a viable path for the clinical realization of neuroprotection in patients with depression by attenuating biological mechanisms associated with neuroprogression.
Why the study?
Perioperative pain control plays an important role in postoperative convalescence, leading investigators to evaluate the effect of dexmedetomidine on postoperative pain in patients undergoing abdominal hysterectomy.
Does intravenous dexmedetomidine reduce postoperative pain intensity in women undergoing abdominal hysterectomy?
Population
70 women aged 35-65 years undergoing general anaesthesia for TAH
Comparison
Intravenous dexmedetomidine vs normal saline
Design
Double-blind randomized controlled clinical trial
Follow-up
24 hours after surgery
Authors
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May guide adjunctive regimens in depression; extends neuroprotection data from mechanisms to RCTs.
Does intravenous dexmedetomidine reduce postoperative pain intensity in women undergoing abdominal hysterectomy?
Intravenous dexmedetomidine significantly reduces postoperative pain intensity up to 24 hours after abdominal hysterectomy.
Nesioonpour et al. (2020) conducted a review in Depression (n=19). Neuroprotective agents was evaluated. Adjuvant use of multiple drug agents may present a viable path for the clinical realization of neuroprotection in patients with depression by attenuating biological mechanisms associated with neuroprogression.
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