Key result
Intravenous dexmedetomidine infusion significantly lowered postoperative levels of interleukin-6, cortisol, blood glucose, and pain scores compared to placebo in major abdominal surgery.
Why the study?
Does intravenous dexmedetomidine infusion reduce stress response markers and postoperative pain in adult patients undergoing major abdominal surgery?
RCT (n=30)
Randomly classified
No
Does intravenous dexmedetomidine infusion reduce stress response markers and postoperative pain in adult patients undergoing major abdominal surgery?
Intravenous dexmedetomidine during major abdominal surgery effectively blunts the postoperative stress response and reduces pain without significantly delaying recovery.
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Supports dexmedetomidine infusion to reduce postoperative stress and pain in major abdominal surgery; confirms RCT benefits on inflammatory markers.
Yacout et al. (2011) conducted an RCT in Elective major abdominal surgery (n=30). Intravenous dexmedetomidine infusion vs. Intravenous infusion of normal saline (placebo) was evaluated on Stress response markers (plasma interleukin-6, cortisol and blood glucose level). Intravenous dexmedetomidine infusion significantly lowered postoperative levels of interleukin-6, cortisol, blood glucose, and pain scores compared to placebo in major abdominal surgery.
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