July 1, 2018SVU-International Journal of Medical SciencesOpen Access

Effect of Intravenous Dexmedetomidine Infusion on Interleukin-6 (IL-6) and Plasma Cortisol in Open Heart Surgery

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Why the study?

Does intravenous dexmedetomidine infusion reduce stress response markers (IL-6 and cortisol) in patients undergoing elective open heart surgery with CPB?

Structured PICO

Does intravenous dexmedetomidine infusion reduce stress response markers (IL-6 and cortisol) in patients undergoing elective open heart surgery with CPB?

Population

n=50 consecutive patients aged 18-70 years, scheduled for elective open heart surgery using cardiopulmonary bypass (CPB) technique.

Intervention

Dexmedetomidine loading dose of 1 μg/kg IV dissolved in 20ml normal saline over 10 minutes followed by maintenance dose of 0.5 μg/kg/hr till the end of surgery.

Comparator

Placebo (20ml intravenous infusion of normal saline 0.9% over 10 minutes followed by continuous infusion of 12.5 ml of normal saline till the end of surgery).

Outcome

Stress response markers (plasma interleukin-6 and plasma cortisol).surrogate

Intravenous dexmedetomidine during open heart surgery with CPB safely suppresses inflammatory and stress responses while stabilizing hemodynamics.

Discussion

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Implication

Supports dexmedetomidine to blunt stress markers in CPB surgery; confirms anti-inflammatory effects in RCT.

Cite This Study

Youssef et al. (2018) studied this question.

synapsesocial.com/papers/6a84fc945c0b46d4e2990e00 https://doi.org/10.21608/svuijm.2018.120566

View Full Paper

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Effect of Intravenous Dexmedetomidine Infusion on Interleukin-6 (IL-6) and Plasma Cortisol in Open Heart Surgery

Structured PICO

Discussion

Implication

Cite This Study

Effect of Intravenous Dexmedetomidine Infusion on Interleukin-6 (IL-6) and Plasma Cortisol in Open Heart Surgery

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider