Associations between adolescent adversity and young adult depression symptoms and allostatic load in Mexican-origin individuals

Childhood adversity increases risk for depression and higher allostatic load (AL), defined as long-term wear and tear on the body, and adolescence is an especially sensitive time for adversity to be biologically embedded. Individuals of Mexican origin may face multiple forms of adversities relating to their intersectional identities of ethnicity and class, including ethnic discrimination and economic hardship, the experience of which may further depend on sex. However, relatively little research has simultaneously assessed associations between these two types of adolescent adversity and outcomes of both young adult depression and AL longitudinally in Mexican-origin individuals. This preregistered study addressed these gaps in a longitudinal study of 208 Mexican-origin participants. Ethnic discrimination and economic hardship were assessed annually from ages 10 to 19 and AL and depression symptoms were assessed at age 26. Sex differences were also tested. Perceived discrimination in adolescence significantly predicted higher levels of depression at age 26 (β =.09, p =.045, R 2 =.03, ΔR 2 = 0.005, 95% CI [.002,.181]). In addition, age 26 depression levels moderated the association between adolescent economic hardship and age 26 AL (β = -.17, p =.03, R 2 =.12, ΔR 2 =.028, 95% CI [-.33, -.02]). Participants exhibited higher AL with high levels of economic hardship but low levels of depression, as well as with low levels of economic hardship and high depression, suggesting that both psychological resilience to economic hardship and the association between mental health and AL may depend on context. Findings indicate intersectional effects of different types of adversity during adolescence on mental and physical health in young adulthood within Latino individuals. • Greater ethnic discrimination in adolescence predicted higher young adult depression • Those with high economic hardship yet low depression exhibited worse health • For economic hardship, psychological resilience may come at cost of physical health • Findings suggest distinct effects of discrimination and economic hardship