Why the study?
Depression is strongly associated with chronic disease, but the direction of this relationship is poorly understood.
Population
620 adults (45-75 years) enrolled in the Boston Puerto Rican Health Study
Comparison
Baseline depressive symptom categories and baseline allostatic load categories
Design
Longitudinal cohort study
Follow-up
5 years
Authors
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Supports joint monitoring of symptoms and dysregulation in at-risk adults; leaves open whether intervening on one alters the other.
There is a bidirectional relationship between depressive symptoms and allostatic load over 5 years among Puerto Rican older adults, suggesting a nuanced pathway linking depression and chronic disease.
McClain et al. (2021) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: