Key result
Compliance with anti-hypertensive therapy was associated with significantly better blood pressure control compared to non-compliance (45.9% vs 27.3%, p=0.007).
Why the study?
What is the compliance rate and what factors affect non-compliance with anti-hypertensive therapy in Nigerian patients?
Cross-Sectional (n=225)
No
What is the compliance rate and what factors affect non-compliance with anti-hypertensive therapy in Nigerian patients?
Absolute Event Rate: 45.9% vs 27.3%
p-value: p=0.007
Non-compliance with anti-hypertensive therapy is common (34.2%) among Nigerian patients, largely driven by patient attitudes, beliefs, and lack of finances, and is associated with poorer blood pressure control.
Association with better control supports adherence efforts in Nigerian patients; cross-sectional data leaves open causality and generalizability.
BACKGROUND: Non-compliance with antihypertensive drug therapy can have a negative impact on cardiovascular outcome. The objective of this study was to determine compliance rate with anti-hypertensive therapy and factors affecting compliance among patients attending a Nigerian tertiary hospital. METHODS: A cross sectional study was conducted on 225 black hypertensive patients attending a tertiary clinic in Lagos, Nigeria. Demographic data, current anti-hypertensive therapy, compliance with prescribed therapy, factors affecting compliance and BP were documented via an investigator administered questionnaire and open-ended interviews. RESULTS: In this study, 77(34.2%) of the hypertensive patients were non-compliant. Blood pressure control was significantly better among compliant patients (45.9%) than in non-compliant patients (27.3%) (x(2) = 7.35 p=0.007). Gender, age, number of drugs used, educational level and presence of co-morbidities did not affect compliance. The major reasons for non-compliance were miscellaneous factors (60%) related to both patient's attitudes and beliefs (reflecting ignorance),and consultation failure on the part of clinicians. Lack of finances and side effects of medications accounted for 23.8% and 16.2% of non-compliances respectively. CONCLUSION: Although lack of finances is the single most self reported reason, miscellaneous factors related to patients' attitudes and belief contribute frequently. Incorporating patient education and counselling in routine follow-up may improve compliance, BP control, and ultimately impact positively on cardiovascular outcome.
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Amira et al. (2007) conducted a cross-sectional in Hypertension (n=225). Anti-hypertensive drug therapy compliance vs. Non-compliance was evaluated on Blood pressure control (p=0.007). Compliance with anti-hypertensive therapy was associated with significantly better blood pressure control compared to non-compliance (45.9% vs 27.3%, p=0.007).
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