Key result
Text provides no clinical data, containing only journal editorial board and publication information.
Why the study?
Mitral regurgitation and severe aortic valve stenosis frequently coexist, and concomitant double-valve replacement carries high morbidity and mortality, prompting investigation into MR progression after isolated aortic valve replacement.
Does isolated aortic valve replacement improve mitral regurgitation in patients with severe aortic stenosis and moderate to severe functional mitral regurgitation?
Does isolated aortic valve replacement improve mitral regurgitation in patients with severe aortic stenosis and moderate to severe functional mitral regurgitation?
Isolated aortic valve replacement significantly reduces coexisting moderate-to-severe functional mitral regurgitation, suggesting concomitant mitral surgery may not be strictly necessary in this high-risk population.
Question of concomitant mitral surgery in severe AS with moderate-severe functional MR remains open; observational data insufficient to guide practice.
Objective Mitral regurgitation (MR) and severe aortic valve stenosis often coexist. Concomitant replacement of both valves is associated with a significantly higher morbidity and mortality. This study sought to investigate the progression of MR after isolated aortic valve replacement. Methods We analyzed the severity and progression of MR, survival and echocardiographic parameters in 506 patients with severe aortic valve stenosis and moderate to severe functional MR who received isolated aortic valve replacement during a 9-year period. Results Transcatheter aortic valve implantation (TAVI) was performed in 381 patients and 125 patients received surgical aortic valve replacement (SAVR). The median age of the cohort was 82 years. Median ejection fraction before and after TAVI or SAVR was 35 and 36% respectively (p = 0.64). There was a statistically significant reduction in the MR (p < 0.001) within both groups. Survival in both groups at 5 years was at 25%. Conclusion Isolated aortic valve replacement in patients with accompanying moderate to severe functional MR may present an adequate treatment option for this high-risk patient collective.
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Pingpoh et al. (2021) studied this question. No clinical study data is present in the provided text, which consists only of the journal's editorial board and publication information.
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