Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 19, 2026Comparative Biochemistry and Physiology Part C Toxicology & PharmacologyOpen Access

Behavioral, biochemical, and endocrine stress responses in zebrafish exposed to azithromycin, nimesulide, and their combination

View Full Paper
Ask AI
Bookmark
Share

Authors

PAPaola Aparecida de AlmeidaUniversidade de Passo FundoWTWagner Antonio TamagnoPurdue University West LafayetteFAFrancieli Ubirajara Índia AmaralUniversidade de Passo Fundo

Discussion

Loading...

Member takes

Implication

Randomized trial reveals that pharmaceutical exposure disrupts stress responses in zebrafish, indicating ecological risks.

Key Points

  • The study aims to assess the behavioral, biochemical, and endocrine stress responses in zebrafish exposed to azithromycin and nimesulide.
  • Zebrafish were exposed to azithromycin, nimesulide, and a combination of both compounds.
  • Various behavioral tests, including the Novel Tank Test and Social Preference Test, were conducted.
  • Biochemical markers such as cortisol, AChE activity, and TBARS were measured to assess stress responses.
  • Nimesulide significantly reduced locomotion (~30%) and increased anxiety-like behavior (p < 0.05).
  • Cortisol levels increased with azithromycin exposure and were further elevated with combined exposure (p < 0.01).
  • Nimesulide increased TBARS levels, indicating oxidative damage, while the combination treatment raised CAT activity.

Cite This Study

Almeida et al. (2026) studied this question.

synapsesocial.com/papers/6a0bfd3f166b51b53d378c1bhttps://doi.org/10.1016/j.cbpc.2026.110581
View Full Paper
Ask AI
Bookmark
Share