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August 2, 2026Brain SciencesOpen Access

Neurobehavioral Effects of Two Distinct Anti-Inflammatory Drugs in a Two-Week Chronic Stress Model in Zebrafish

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Authors

МKМ. М. KotovaTKTatiana O. KolesnikovaSAS. V. Amikishiev

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Overview

Randomized trial examines anti-inflammatory drugs' effects on behavior and biomarkers in zebrafish, indicating different therapeutic benefits.

Key Points

  • This research aims to investigate the neurobehavioral effects of minocycline and nimesulide in a chronic stress zebrafish model.
  • Chronic stress was induced in zebrafish using a two-week unpredictable stress model.
  • Zebrafish were treated with either minocycline (50 mg/L) or nimesulide, followed by behavioral assessments.
  • Expression levels of neuroinflammation-related biomarkers were analyzed post-treatment.
  • Minocycline reduced motor activity and downregulated pro-inflammatory markers (nos2a, cox2) and upregulated anti-inflammatory markers (s100a10).
  • Nimesulide exhibited anxiolytic effects, normalizing expression of stress-induced glial biomarkers (cox2, il1β).
  • Minocycline showed broader anti-neuroinflammatory effects, while nimesulide had more specific anxiolytic properties.

Cite This Study

Kotova et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeb101b0468a7eeab3eaehttps://doi.org/10.3390/brainsci16080815
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