Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 12, 2026Journal of Applied Toxicology

Studying the Stress, Gene Expression, and Behavioral Changes Induced by Diazepam and Sertraline in a Zebrafish Model

View Full Paper
Ask AI
Bookmark
Share

Authors

SFShahab Tirgar FakheriIslamic Azad University, BabolRCReza ChangiziIslamic Azad University, BabolHMHamed ManouchehriIslamic Azad University, Babol

Discussion

Loading...

Member takes

Implication

This research investigates behavioral changes due to diazepam and sertraline in zebrafish, indicating their potential as treatment options.

Key Points

  • The aim is to understand how diazepam and sertraline affect stress-induced behavior and gene expression in zebrafish.
  • Utilized the Unpredictable Chronic Stress (UCS) protocol
  • Evaluated behavior using the Novel Tank Test (NTT)
  • Measured cortisol levels for biochemical analysis
  • Analyzed cytokine gene expression (TNF‐α, IL‐6, IL‐10) using RT‐PCR
  • Applied two-way ANOVA for data analysis in SPSS
  • UCS protocol resulted in significant behavioral and neuroendocrine changes
  • Diazepam, sertraline, and their combination improved behavioral outcomes
  • Increased time and number of entries in the top zone of the tank with treatment
  • Treatments reduced expression of inflammatory cytokines TNF‐α and IL‐6
  • Sertraline significantly decreased cortisol levels from 1.01 ± 0.07 ng/g to 0.15 ± 0.04 ng/g

Cite This Study

Tirgar Fakheri et al. (2026) studied this question.

synapsesocial.com/papers/698d6e055be6419ac0d53688https://doi.org/10.1002/jat.70092
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depression and Anxiety During the COVID-19 Pandemic: Epidemiology, Mechanism, and Treatment2022 · 138 citations
  2. 2Chronic Unpredictable Stress Exacerbates Lipopolysaccharide-Induced Activation of Nuclear Factor-κB in the Frontal Cortex and Hippocampus via Glucocorticoid Secretion2006 · 277 citations