Why the study?
Exercise right heart catheterization is a valuable diagnostic tool for identifying hemodynamic abnormalities that may not be evident at rest.
Exercise right heart catheterization can reveal latent pulmonary hypertension in patients with unexplained exertional symptoms when resting measurements are nondiagnostic.
Exercise RHC may aid evaluation of unexplained exertional symptoms with normal resting hemodynamics; leaves open prospective validation of EIPAH criteria.
BACKGROUND: Exercise right heart catheterization (RHC) is a valuable diagnostic tool for identifying hemodynamic abnormalities that may not be evident at rest. CASE SUMMARY: A 36-year-old woman presented with recurrent exertional syncope and dyspnea. Initial resting studies were inconclusive. Resting RHC revealed mild precapillary pulmonary hypertension (PH). However, exercise RHC unmasked a disproportionate increase in mean pulmonary artery pressure during exertion, diagnostic of exercise-induced pulmonary arterial hypertension (EIPAH). Vasoreactivity testing with inhaled nitric oxide demonstrated favorable pulmonary vascular responsiveness. Autoimmune workup confirmed systemic lupus erythematosus. The patient was started on medical therapy and referred to rheumatology and the PH clinic. DISCUSSION: This case highlights the role of exercise RHC in detecting early pulmonary vascular disease and supports vasoreactivity testing to guide therapy. EIPAH may be the initial manifestation of autoimmune disease and should be considered in young patients with exertional symptoms and nondiagnostic resting evaluations. TAKE-HOME MESSAGES: Exercise RHC can reveal latent PH when resting measurements are nondiagnostic. In patients with unexplained exertional symptoms, EIPAH should be considered. EIPAH may be the initial manifestation of an underlying autoimmune condition such as systemic lupus erythematosus.
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Habib et al. (2025) studied this question.
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