Key result
An RS time cut-off of 59.5 ms was significantly associated with survival in patients with pulmonary arterial hypertension (HR 0.06; 95% CI 0.02-0.17; p<0.001).
Why the study?
Pulmonary arterial hypertension involves right ventricular remodeling associated with prognosis, which may be reflected in electrocardiographic parameters.
Is RS time on electrocardiogram associated with survival in patients with pulmonary arterial hypertension?
Cohort
Is RS time on electrocardiogram associated with survival in patients with pulmonary arterial hypertension?
Answers are grounded in this paper and cite their sources.
A longer RS time (≥59.5 ms) on ECG is a simple, non-invasive marker independently associated with poor survival in patients with pulmonary arterial hypertension.
Background: Pulmonary hypertension is a condition that involves the remodeling of the right ventricle. Ongoing remodeling is also associated with disease prognosis. During the restructuring process, complex changes such as hypertrophy and dilatation may also be reflected in electrocardiographic parameters. Objectives: Our study aimed to investigate the relationship between prognosis and electrocardiographic parameters in patients with pulmonary arterial hypertension. Methods: The study was designed retrospectively and included patients diagnosed with pulmonary arterial hypertension between 2010 and 2022. The patients were divided into two groups based on their survival outcome. Various parameters, including electrocardiographic, demographic, echocardiographic, catheter, and blood parameters, were compared between the two groups. A p-value of <0.05 was considered statistically significant. Results: In the multivariate Cox analyses, the parameters that were found to be independently associated with survival were the 6-minute walk test, mean pulmonary artery pressure, presence of pericardial effusion, and time between the beginning of the QRS and the peak of the S wave (RS time) (p<0.05 for each). Of all the parameters, RS time demonstrated the best diagnostic performance (AUC:0.832). In the survival analysis, a significant correlation was found between RS time and survival when using a cut-off value of 59.5 ms (HR: 0.06 [0.02-0.17], p < 0.001). Conclusions: According to the results of our study, a longer RS time is associated with poor prognosis in patients with pulmonary arterial hypertension. We can obtain information about the course of the disease with a simple, non-invasive parameter.
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Koyun et al. (2024) conducted a cohort in Pulmonary arterial hypertension. RS time (time between beginning of QRS and peak of S wave) vs. RS time cut-off of 59.5 ms was evaluated on Survival (HR 0.06, 95% CI 0.02-0.17, p=< 0.001). An RS time cut-off of 59.5 ms was significantly associated with survival in patients with pulmonary arterial hypertension (HR 0.06; 95% CI 0.02-0.17; p<0.001).
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