Key result
Systemic sclerosis is linked to ~88% higher pulmonary artery stiffness versus healthy controls.
Why the study?
The study aimed to evaluate pulmonary artery stiffness for the early diagnosis of systemic sclerosis and pulmonary hypertension in systemic sclerosis patients.
Does pulmonary artery stiffness measured by echocardiography increase in patients with systemic sclerosis compared to healthy controls?
Case-Control (n=147)
Single-blind
No
Does pulmonary artery stiffness measured by echocardiography increase in patients with systemic sclerosis compared to healthy controls?
Pulmonary artery stiffness is significantly increased in patients with systemic sclerosis even before the development of overt pulmonary hypertension, suggesting its utility as an early echocardiographic marker of pulmonary vascular disease.
Answers are grounded in this paper and cite their sources.
Supports echo stiffness measurement as early marker in systemic sclerosis; leaves open prognostic value and therapeutic implications.
Objective: The study aims to investigate the use of pulmonary artery stiffness (PAS) parameter in early diagnosis of systemic sclerosis (SSc) and pulmonary hypertension in SSc patients. Patients and Methods: The study involved 102 SSc patients and 45 control group patients, who underwent transthoracic echocardiographic evaluations. Results: Pulmonary artery stiffness was measured as 25.7±7.6 (Hz/msn) in the SSc cases and 13.7 ±1.6 (Hz/msn) in the healthy subjects (P< 0.001). TAPSE/sPAP ratio, which we used as an indicator of RV-PA coupling, was calculated as 0.65+0.28 in SSc cases and 1.12+0.33 in the control group (P<0.001). When we evaluated PAS values of subgroups PAS was significantly higher in SScPH(-) patients without pulmonary hypertension than control subjects (respectively; 21.67 ± 3.9; 13.7 ± 1.6, P<0.001). The relationship of PAS with the parameters in which pulmonary hypertension and right ventricular functions were evaluated, there was a positive correlation with sPAP( r: – 0.396, P <0.001), while a negative correlation was observed with TAPSE/sPAP (r: 0.456, P<0.001). Conclusion: We observed higher PAS values in SScPH(-) patients compared to the control group and found a positive correlation between the increase in PAS and sPAP and a negative correlation between them and TAPSE/sPAP.
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Akaslan et al. (2023) conducted a case-control in Systemic sclerosis (n=147). Systemic sclerosis vs. Healthy controls was evaluated on Pulmonary artery stiffness (PAS) (p=<0.001). Systemic sclerosis patients had higher pulmonary artery stiffness compared to healthy controls.
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