Key result
TAPSE/sPAP ratio correlates with exercise capacity and ventilatory efficiency in systemic sclerosis.
Why the study?
The correlation between CPET parameters and right ventricular echocardiographic parameters for pulmonary arterial hypertension screening in systemic sclerosis patients was not well established.
Cross-Sectional (n=40)
Effect estimate: β = -0.570
p-value: p=<0.0001
In patients with systemic sclerosis, the echocardiographic TAPSE/sPAP ratio correlates significantly with ventilatory efficiency and exercise capacity, supporting its potential utility in screening for pulmonary arterial hypertension.
May support CPET as adjunctive PAH screen in SSc; leaves open added value beyond resting echocardiography.
Objectives The aim of the study was to evaluate the correlation between cardiopulmonary exercise testing (CPET) parameters and right ventricular echocardiographic parameters for pulmonary arterial hypertension screening in a cohort of systemic sclerosis (SSc) patients. Methods forty SSc patients were examined using CPET and resting transthoracic echocardiography. CPET parameters analyzed were minute ventilation/carbon dioxide production (VE/VCO2) slope and maximum oxygen uptake (VO2 max); echocardiographic parameters were systolic pulmonary artery pressure (sPAP), tricuspid annular plane systolic excursion (TAPSE), and TAPSE/sPAP ratio. Results a positive correlation was observed between VE/VCO2 slope and age (r = 0.415, p < 0.01) and sPAP (r = 0.461, p < 0.01), conversely, a negative correlation was found between VE/VCO2 slope and TASPE/sPAP ratio (r = − 0.521, p = 0.001). VO2 max showed an inverse correlation with age (r = − 0.367, p < 0.05) and sPAP (r = − 0.387, p < 0.05) and a positive correlation with TAPSE/sPAP ratio (r = 0.521, p < 0.01). On stepwise linear regression analysis, VE/VCO2 slope was significantly correlated with TAPSE/sPAP ratio (β coefficient = − 0.570; p < 0.0001), as well as VO2 max was significantly correlated with TAPSE/sPAP ratio (β coefficient = 0.518; p = 0.001). Conclusion in SSc patients, TAPSE/sPAP ratio is the echocardiographic parameter of RV function which showed the best correlation with ventilatory efficiency and exercise capacity.
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Colalillo et al. (2022) conducted a cross-sectional in Systemic sclerosis (n=40). TAPSE/sPAP ratio was evaluated on Correlation between VE/VCO2 slope and TAPSE/sPAP ratio (β = -0.570, p=<0.0001). In patients with systemic sclerosis, the TAPSE/sPAP ratio was significantly correlated with ventilatory efficiency (VE/VCO2 slope, β = -0.570) and exercise capacity (VO2 max, β = 0.518).
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