What question did this study set out to answer?

To identify specific susceptibility windows to air pollution exposure from conception to preadolescence regarding white matter microstructure and brain volumes at 9–12 years of age.

September 22, 2022Environmental PollutionOpen Access

Air pollution, white matter microstructure, and brain volumes: Periods of susceptibility from pregnancy to preadolescence

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To identify specific susceptibility windows to air pollution exposure from conception to preadolescence regarding white matter microstructure and brain volumes at 9–12 years of age.
Analyzed data from N=3,515 children in the Generation R population-based birth cohort in Rotterdam, the Netherlands (2002–2006).
Estimated daily residential NO2, PM2.5, and PM2.5absorbance levels from pregnancy through childhood using land-use regression models.
Assessed brain structural volumes and diffusion tensor imaging metrics (fractional anisotropy and mean diffusivity) at ages 9–12 years using distributed lag non-linear models adjusted for socioeconomic and lifestyle factors.
Air pollution exposure from conception to age 5 years was significantly associated with lower fractional anisotropy and higher mean diffusivity across all pollutants, including a −0.85 reduction in fractional anisotropy (95% CI, −1.43 to −0.27) per 5 μg/m³ increase in PM2.5 between conception and 4 years of age.
PM2.5 exposure between 4 months and 1.8 years of age was associated with an increase in putamen volume (172 mm³ [95% CI, 57 to 286] per 5 μg/m³ increase) after multiple testing correction.

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Implication

Cohort study reveals altered white matter microstructure in preadolescents exposed to early air pollution, highlighting critical susceptibility windows from conception to age five.

Cite This Study

Binter et al. (2022) studied this question.

synapsesocial.com/papers/6a0c699b63ad68335d233b32 https://doi.org/10.1016/j.envpol.2022.120109

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Implication

Cohort study reveals altered white matter microstructure in preadolescents exposed to early air pollution, highlighting critical susceptibility windows from conception to age five.

Air pollution, white matter microstructure, and brain volumes: Periods of susceptibility from pregnancy to preadolescence

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Discussion

Implication

Cite This Study

Air pollution, white matter microstructure, and brain volumes: Periods of susceptibility from pregnancy to preadolescence

Key Points

Discussion

Implication

Cite This Study

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