Physical activity and diet just-in-time adaptive intervention to reduce blood pressure: a randomized controlled trial

Mobile health interventions for behavioral change require large-scale studies to ensure their clinical benefits. We conducted a randomized controlled trial of patients with hypertension to assess the myBPmyLife application in promoting physical activity and lower-sodium foods to lower systolic blood pressure (SBP). 602 participants were randomly assigned to either a control group or an intervention group that received the myBPmyLife application. For the primary outcome, change in SBP over 6 months was -5.2 mmHg in the intervention and -5.7 mmHg in the control group (p = 0.76). For secondary outcomes, the intervention group increased their daily step count by 170 steps, while the control group decreased by 319 steps (p = 0.040). Sodium intake decreased by 1145 mg in the intervention and 860 mg in the control group (p = 0.002). The myBPmyLife application did not reduce SBP over 6 months in hypertension patients despite increasing step counts and lowering sodium intake. ClinicalTrials.gov registration: NCT05154929, 12/2021.