What is the clinical evidence from this study?

Study design: Case Report. Population: Virus-induced rhabdomyolysis (n=4).

May 9, 2025Frontiers in PediatricsOpen Access

Case Report: Virus-induced rhabdomyolysis ranging from mild course to acute renal injury, hyperferritinemia and poor outcome: a case series of four pediatric patients

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Key result

Marked hyperferritinemia may predict disease severity and AKI in pediatric virus-induced rhabdomyolysis.

Population

Four healthy pediatric patients presenting with virus-induced rhabdomyolysis

Design

Case series

Authors

CZCarlijn W. van der ZeeEmma Kinderziekenhuis GBGiske BiesbroekEmma Kinderziekenhuis MOMichiel J.S. OosterveldEmma Kinderziekenhuis

Discussion

Member takes

Implication

May warrant monitoring in severe pediatric cases; hypothesis-generating and requires prospective validation.

Study Design

Type

Case Report (n=4)

Multicenter

Structured PICO

Population

n=4 pediatric patients with virus-induced rhabdomyolysis (2 with influenza A, 1 with parainfluenza/enterovirus, 1 with cytomegalovirus), ages 2-14 years, 1 male and 3 females.

Intervention

Supportive care including hyperhydration; one severe case received mechanical ventilation, continuous hemodiafiltration, and daily plasmapheresis.

Outcome

Clinical outcome including development of acute kidney injury, liver failure, and mortality during hospital admission.

Hyperferritinemia may serve as a biomarker for disease severity and acute kidney injury in pediatric patients with virus-induced rhabdomyolysis.

Limitations

Small sample size with only two patients having a severe outcome
A larger cohort is needed to empower the hypothesis that hyperferritinemia may be a predictor for severe outcome
only includes two patients with severe outcome in virus-induced rhabdomyolysis
A larger cohort is needed to empower our hypothesis that hyperferritinemia may be a predictor for severe outcome

Cite This Study

Zee et al. (2025) conducted a case report in Virus-induced rhabdomyolysis (n=4). Among four pediatric patients with virus-induced rhabdomyolysis, two with influenza A developed acute kidney injury and marked hyperferritinemia, suggesting ferritin may predict disease severity.

synapsesocial.com/papers/6a0c70f8e8a76b3043887d33 https://doi.org/10.3389/fped.2025.1552232

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Case Report: Virus-induced rhabdomyolysis ranging from mild course to acute renal injury, hyperferritinemia and poor outcome: a case series of four pediatric patients

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Case Report: Virus-induced rhabdomyolysis ranging from mild course to acute renal injury, hyperferritinemia and poor outcome: a case series of four pediatric patients

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider