Patterns of recurrence in extremity liposarcoma
Key result
Myxoid liposarcomas metastasized to extrapulmonary sites significantly more frequently than pleomorphic tumors (30.4% vs 16.7%; P<0.05).
Why the study?
Do patterns of recurrence differ between histologic subtypes of extremity liposarcoma?
Population
122 patients with intermediate or high grade extremity liposarcoma referred to the University of Texas M. D…
Design
Cohort
Follow-up
median 70 months
Authors
Discussion
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Implication
Metastatic patterns differed by liposarcoma subtype; hypothesis-generating for histology-specific surveillance strategies.
Study Design
Type
Cohort (n=122)
Multicenter
No
Structured PICO
Do patterns of recurrence differ between histologic subtypes of extremity liposarcoma?
P
Population
122 patients with intermediate or high grade extremity liposarcoma (102 myxoid, 18 pleomorphic, 2 mixed) referred to the University of Texas M. D. Anderson Cancer Center from January 1, 1980, to December 31, 1992.
C
Comparator
Pleomorphic subtype (for comparison of recurrence patterns with myxoid subtype)
O
Outcome
Patterns of recurrence (extrapulmonary vs. lung only) and survival rates (overall, local recurrence free, distant recurrence free, disease free)hard clinical
Main Result
Absolute Event Rate: 30.4% vs 16.7%
p-value: p=< 0.05
Myxoid liposarcomas metastasize significantly more frequently to extrapulmonary soft tissue sites compared to pleomorphic tumors, which primarily metastasize to the lungs, necessitating different staging and follow-up imaging strategies.
Cite This Study
Pearlstone et al. (1999) conducted a cohort in Extremity liposarcoma (n=122). Myxoid subtype vs. Pleomorphic subtype was evaluated on Distant recurrence to extrapulmonary soft tissue sites (p=< 0.05). Myxoid liposarcomas metastasized to extrapulmonary sites significantly more frequently than pleomorphic tumors (30.4% vs 16.7%; P<0.05).