Histologic Subtype and Margin of Resection Predict Pattern of Recurrence and Survival for Retroperitoneal Liposarcoma
Key result
Dedifferentiated histologic subtype was associated with a 6-fold increased risk of death compared with well-differentiated histology in primary retroperitoneal liposarcoma (P < 0.0001).
Why the study?
Do histologic subtype and margin of resection predict recurrence and survival in patients with primary retroperitoneal liposarcoma?
Population
177 patients with primary retroperitoneal liposarcoma operated on for curative intent between July 1982 and…
Design
Cohort
Follow-up
median 37 months for surviving patients
Authors
Discussion
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Member takes
Implication
May guide subtype-based risk stratification in retroperitoneal liposarcoma; leaves open prospective validation of management implications.
Study Design
Type
Cohort (n=177)
Structured PICO
Do histologic subtype and margin of resection predict recurrence and survival in patients with primary retroperitoneal liposarcoma?
P
Population
177 patients with primary retroperitoneal liposarcoma operated on for curative intent between July 1982 and June 2002
I
Intervention
Surgical resection
O
Outcome
Local recurrence, distant recurrence, and disease-specific survivalhard clinical
Main Result
Effect estimate: 6-fold increased risk
p-value: p=< 0.0001
Histologic subtype and margin of resection are significant prognostic factors for survival and recurrence in primary retroperitoneal liposarcoma.
Cite This Study
Singer et al. (2003) conducted a cohort in Primary retroperitoneal liposarcoma (n=177). Dedifferentiated histologic subtype and incomplete resection vs. Well-differentiated histologic subtype and complete resection was evaluated on Disease-specific survival (6-fold increased risk, p=< 0.0001). Dedifferentiated histologic subtype was associated with a 6-fold increased risk of death compared with well-differentiated histology in primary retroperitoneal liposarcoma (P < 0.0001).