April 25, 2015Annals of Surgery
Histology-based Classification Predicts Pattern of Recurrence and Improves Risk Stratification in Primary Retroperitoneal Sarcoma
Key result
Histologic type/subtype is an independent predictor of disease-specific death (31% at 5 years), local recurrence (39%), and distant recurrence (24%) in primary retroperitoneal sarcoma.
Why the study?
Does histologic type/subtype predict disease-specific death, local recurrence, and distant recurrence in patients with primary resected retroperitoneal sarcoma?
Population
675 patients treated surgically for primary, nonmetastatic retroperitoneal sarcoma during 1982 to 2010
Design
Cohort
Follow-up
Median 7.5 years for survivors
Authors
Discussion
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Member takes
Implication
Supports histology-based risk stratification after resection; leaves open impact on adjuvant decisions or surveillance intensity.
Study Design
Type
Cohort (n=675)
Multicenter
No
Structured PICO
Does histologic type/subtype predict disease-specific death, local recurrence, and distant recurrence in patients with primary resected retroperitoneal sarcoma?
P
Population
675 patients treated surgically for primary, nonmetastatic retroperitoneal sarcoma, followed for a median of 7.5 years.
E
Exposure
Histologic classification of resected retroperitoneal sarcoma
O
Outcome
Disease-specific death (DSD), local recurrence (LR), and distant recurrence (DR)hard clinical
Histologic type/subtype is a critical independent predictor of recurrence patterns and survival in primary retroperitoneal sarcoma, enabling better risk stratification.
Cite This Study
Tan et al. (2015) conducted a cohort in primary retroperitoneal sarcoma (n=675). Histologic type/subtype was evaluated on disease-specific death (DSD), local recurrence (LR), and distant recurrence (DR). Histologic type/subtype is an independent predictor of disease-specific death (31% at 5 years), local recurrence (39%), and distant recurrence (24%) in primary retroperitoneal sarcoma.